1) Cat. No.: TRC-A425000; 2) Chemical Name: AG-490; 3) CAS No.: 134036-52-5; 4) Mol. Formula: C17H14N2O3; 5) Mol. Weight: 294.3; 6) Packing Size: 25mg / 250mg; 7) Appearence: Dark Yellow Solid; 8) Application Notes: A potent and specific inhibitor of the Jak-2 tyrosine kinase.  In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src.  AG-490 is cell permeable and is active in vivo.; 9) Synonym: 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; Tyrphostin B 42;; 10) Solubility: Acetone, Chloroform, DMSO, Ethanol, Methanol; 11) Storage condition: -20°C Freezer; 12) References: Stock, J., et al.: J. Biol. Chem., 267, 19753